Erythrocyte membrane transport of glutathione conjugates and oxidized glutathione in the dubin-johnson syndrome and in rats with hereditary hyperbilirubinemia
✍ Scribed by Philip Board; Toshirou Nishida; Zenaida Gatmaitan; Mingxin Che; Irwin M. Arias
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 504 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
The Dubin-Johnson syndrome is manifested by conjugated hyperbilirubinemia and pigment accumulation in hepatocellular lysosomes. The TR-rat model is a phenotypic model of the Dubin-Johnson syndrome and is characterized by defective ATP-dependent transport of a group of nonbile acid organic anions, including glutathione-S-conjugates and oxidized glutathione, across the bile canaliculus. Similar ATPdependent transport mechanisms have been described in erythrocytes. Intact erythrocytes and inverted erythrocyte membrane vesicles from Dubin-Johnson patients, TR-rats and appropriate controls were studied with regard to ATP-dependent transport of dinitrophenyl glutathione and oxidized glutathione. No significant differences were observed, indicating that the erythrocyte and canalicular ATP-dependent transporters for these substrates are functionally and potentially genetically distinct. (HEPATOLOGY 1992;15: 722-725.)