Analysis of peripheral blood (>85% CD19+/CD5+ B) lymphocytes, obtained from 44 patients affected by B chronic lymphoid leukemia (B-CLL), showed that surface TNF-related apoptosis inducing ligand (TRAIL) was expressed in all samples and at higher levels with respect to unfractionated lymphocytes and
Membrane expression of IL-1 alpha in chronic B lymphocytic leukemia
✍ Scribed by Miguel Aguilar-Santelises; Håakan Mellstedt; Mikael Jondal
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 343 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0165-2478
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In order to study if enzymes of purine metabolism could be used as cell markers in B-chronic lymphocytic leukemia (B-CLL), the activities of adenosine deaminase (ADA), purine nucleoside phosphorylase (PNP), and 5'-nucleotidase (5") were repeatedly measured in blood mononuclear cells from B-CLL patie
## Abstract In order to identify regulatory genes involved in the development of an apoptosis‐resistant phenotype in patients with chemotherapy refractory B‐cell chronic lymphocytic leukemia (B‐CLL) expression of apoptosis‐regulating genes in B‐CLL cells was quantified using cDNA arrays and RT‐PCR.