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Membrane adhesion and other functions for the myelin basic proteins

✍ Scribed by Susan M. Staugaitis; David R. Colman; Liliana Pedraza

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 853 KB
Volume: 18
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.950180106

No coin nor oath required. For personal study only.

✦ Synopsis

The myelin basic proteins are a set of peripheral membrane polypeptides which play an essential role in myelination. Their most well-documented property is the unique ability to 'seal' the cytoplasmic aspects of the myelin membrane, but this is probably not the only function for these highly charged molecules. Despite extensive homology, the individual myelin basic proteins (MBPs) exhibit different expression patterns and biochemical properties, and so it is now believed that the various isoforms are not functionally equivalent in myelinating cells. We now think that while the major MBPs are intracellular adhesion molecules, some of the quantitatively less abundant isoforms that are expressed very early in Accepted development may have regulatory effects on the myelination program.

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