Separate regulation of a membrane protein, gp130, present in receptor complex specific for interleukin-6 and other functionally related cytokines
✍ Scribed by András Falus; Judit Biró; Éva Rákász; Thomas Brunner; Stephan Bischoff
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 509 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0952-3499
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✦ Synopsis
Abstract
In addition to specific ligand binding elements, receptor assembly for interleukin(IL)‐6, oncostatin‐M, leukaemia inhibitory factor, ciliary neurotrophic factor and IL‐11 includes and additional unit, gp130. This molecule is a transmembrane glycoprotein of 130 kDa. In this paper, reviewing molecular, biochemical and functional data on gp130, we describe the dissimilar action of IL‐3 on the expression of the binding unit of the IL‐6 receptor and that of gp130. According to FACS studies, resting basophils express only IL‐6 receptors and no gp130 molecules on the plasma membranes. After incubation with IL‐3, the surface appearance and de novo transcription of gp130 was shown by FACS and mRNA polymerase chain reaction analysis.