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Melittin suppresses PMA-induced tumor cell invasion by inhibiting NF-κB and AP-1-dependent MMP-9 expression

✍ Scribed by Jung Hyun Park; Yun-Jeong Jeong; Kwan-Kyu Park; Hyun-Ji Cho; Il-Kyung Chung; Kwan-Sik Min; Mihyun Kim; Kwang-Gill Lee; Joo-Hong Yeo; Kwang-Kyun Park; Young-Chae Chang

Book ID: 106263037
Publisher: Korean Society for Molecular and Cellular Biology
Year: 2010
Tongue: English
Weight: 712 KB
Volume: 29
Category: Article
ISSN: 1016-8478
DOI: 10.1007/s10059-010-0028-9

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✦ Synopsis

Matrix metalloproteinase-9 (MMP-9) plays an important role in the invasion and metastasis of cancer cells. In this study, we examined the inhibitory effect of bee venom (BV) and its major peptides, melittin and apamin, on PMAinduced invasion induced by MMP-9 expression in Caki-1 renal cancer cells. BV and melittin, but not apamin, significantly suppressed PMA-induced invasion by inhibiting MMP-9 expression in Caki-1 cells. Furthermore, as evidenced by MMP-9 promoter assays, melittin inhibited MMP-9 gene expression by blocking the PMA-stimulated activations of activator protein-1 (AP-1) and nuclear factor-kappa B (NF-κB). In addition, melittin suppressed the PMAinduced phosphorylations of ERK and JNK mitogenactivated protein kinases, upstream factors involved in Ap-1 and NF-κB. These results suggest that the suppression of MMP-9 expression contributes to the anti-tumor properties of melittin.

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