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Melittin-phospholipid interaction Evidence for melittin aggregation

✍ Scribed by S. Georghiou; M. Thompson; A.K. Mukhopadhyay

Book ID
115725306
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
232 KB
Volume
642
Category
Article
ISSN
0005-2736

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In aqueous solution, melittin structure, investigated by CD and 'H-nmr, depends on pH and ionic composition, which also regulate the aggregation state of the peptide. When interacting with phospholipids, however, melittin exhibits a right-handed helical conformation without any evidence of oligomeri