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Melatonin and vitamin D3 increase TGF-β1 release and induce growth inhibition in breast cancer cell cultures

✍ Scribed by Mariano Bizzarri; Alessandra Cucina; Maria Giovanna Valente; Fausto Tagliaferri; Valeria Borrelli; Francesco Stipa; Antonino Cavallaro


Book ID
117169329
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
121 KB
Volume
110
Category
Article
ISSN
0022-4804

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In this study, we address whether TGFbeta signaling mediates vitamin D3 analog-induced growth inhibition in nonmalignant and malignant breast cells. Normal mammary epithelial cells (184), immortalized nonmalignant mammary epithelial cells (184A1 and MCF10A), and breast cancer cells (early passage MC