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Melanocytic nevus-like hyperplasia and melanoma in transgenic BRAFV600E mice

✍ Scribed by Goel, V K; Ibrahim, N; Jiang, G; Singhal, M; Fee, S; Flotte, T; Westmoreland, S; Haluska, F S; Hinds, P W; Haluska, F G


Book ID
109972308
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
833 KB
Volume
28
Category
Article
ISSN
0950-9232

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## Abstract The tyrosinase promoter has been used to target expression of the mutated human T24 Ha‐__ras__ oncogene in pigment‐producing cells of transgenic mice. Two independent founder mice carrying the transgene survived and showed the same distinct phenotype of muted coat color, deeply pigmente