Melanocyte chemotactic factor produced by skin metastases of a breast carcinoma

✍ Scribed by Kohki Konomi; Shuhei Imayama; Shonosuke Nagae; Reiji Terasaka; Kazuo Chijiiwa; Yutaka Yashima

• Book ID: 102925321
• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 565 KB
• Volume: 50
• Category: Article
• ISSN: 0022-4790
• DOI: 10.1002/jso.2930500117

✦ Synopsis

A 65-year-old woman underwent right modified radical mastectomy for a malignant lesion which had developed just below the right nipple. Two years after the operation. skin lesions composed of dark brown to black. pigmented. papular lesions developed in the precordia. A biopsy revealed this to be a cutaneous metastasis of the previous breast carcinoma. However numerous pigment blockade melanocytes were also found in the tumor nests, located in and/or beneath the epidermis. Although a black-colored breast carcinoma has been reported, the presence of pigment blockade melanocytes was not determined. Culture of the tumor nest recovered a population of melanocytes as well as the carcinoma cells. Boyden chamber analysis revealed the presence of a chemotactic factor for melanocytes in the culture medium. This seems to be the first documentation of melanocyte incorporation in breast carcinoma tissue.