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Melanocortin circuits in obese mice do not respond to leptin

✍ Scribed by P.J. Enriori; A.E. Evans; P. Sinnayah; M.M. Glavas; K.L. Grove; M.A. Cowley


Book ID
113956862
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
50 KB
Volume
27
Category
Article
ISSN
0091-3022

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## Abstract ## Objective To test the hypothesis that obesity resulting from deletion of the leptin gene or the leptin receptor gene results in increased knee osteoarthritis (OA), systemic inflammation, and altered subchondral bone morphology. ## Methods Leptin‐deficient (__ob__/__ob__) and lepti