33 EXTREME OBESITY DUE TO IMPAIRED LEPTIN SIGNALING DOES NOT CAUSE OSTEOARTHRITIS IN MICE

Extreme obesity due to impaired leptin s

Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis

✍ Timothy M. Griffin; Janet L. Huebner; Virginia B. Kraus; Farshid Guilak 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 235 KB 👁 1 views

## Abstract ## Objective To test the hypothesis that obesity resulting from deletion of the leptin gene or the leptin receptor gene results in increased knee osteoarthritis (OA), systemic inflammation, and altered subchondral bone morphology. ## Methods Leptin‐deficient (__ob__/__ob__) and lepti