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Megestrol acetate in cancer anorexia and weight loss

✍ Scribed by N. Simon Tchekmedyian; Mary Hickman; Jessie Siau; F. Anthony Greco; James Keller; Henry Browder; Joseph Aisner

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
619 KB
Volume
69
Category
Article
ISSN
0008-543X

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✦ Synopsis

Abstract

High‐dose megestrol acetate has been associated with increased appetite and weight. To examine the effects of high‐dose megestrol acetate in the treatment of anorexia and weight loss in patients with advanced hormone‐insensitive malignant lesions, a randomized double‐blind placebo‐controlled trial was conducted. Patients receiving megestrol acetate for 1 month reported a significant improvement in appetite and adequacy of food intake compared with those receiving placebo. A three‐item scale measuring appetite, adequacy of food intake, and concern about weight revealed a higher improvement with megestrol acetate than with placebo. Patients who worsened while receiving placebo had similar favorable changes after the cross over to megestrol acetate. These data indicate that megestrol acetate may improve appetite and food intake in patients with advanced cancer.

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