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Treatment of anorexia and weight loss with megestrol acetate in patients with cystic fibrosis

✍ Scribed by Samya Z. Nasr; Martin E. Hurwitz; Randall W. Brown; Mahmoud Elghoroury; David Rosen

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 22 KB
Volume: 28
Category: Article
ISSN: 8755-6863
DOI: 10.1002/(sici)1099-0496(199911)28:5<380::aid-ppul11>3.0.co;2-a

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✦ Synopsis

Four patients with severe cystic fibrosis lung disease, anorexia and weight loss, received Megestrol Acetate (MA), as an appetite stimulant. The initial dose was 400-800 mg daily and was continued for 6-15 months. Appetite was improved, with significant weight gain in all patients and an increase in their weight for age percentile from <5% at the start of the study to approximately the 25 th percentile after 6 months of use and improvement in quality of life. One patient discontinued MA after 6 months, and subsequently appetite and weight were depressed.

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