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Megakaryoblastic leukemia with involvement of the pleural fluid

✍ Scribed by Daniel Farray; Hytham Al-Masri; Elise Hattersley; Scott E. Smith

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 146 KB
Volume: 79
Category: Article
ISSN: 0361-8609
DOI: 10.1002/ajh.20357

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✦ Synopsis

A 45-year-old woman presented with pancytopenia, hypoxemia, and an elevated lactate dehydrogenase level. An attempt to aspirate the bone marrow was unsuccessful, yielding only a ''dry'' tap. The trephine core biopsy specimen was hypercellular, showing extensive fibrosis along with a marked increased in reticulin fibers but with relatively few immature cells. Immunohistochemical staining of this sample was positive for CD117, CD79a, and CD10 and negative for CD20, CD3, TdT, CD34, pan-keratin, and HMB-45. Because of the inability to aspirate any marrow, there was insufficient material for flow-cytometric analysis. Therefore, two additional bone marrow aspirates

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