Paper electrophoresis of cerebrospinal fluid proteins in patients with meningeal leukemia

✍ Scribed by Arthur R. Rothman; Paul P. Carbone; Richard Rieselbach; Emil J Freireich

• Publisher: John Wiley and Sons
• Year: 1964
• Tongue: English
• Weight: 358 KB
• Volume: 17
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(196406)17:6<798::aid-cncr2820170618>3.0.co;2-i

✦ Synopsis

HE CLINICAL SYNDROME, MENINGEAL LEU-

T kemia, is being increasingly recognized.11

Diagnosis presently depends on the identification of leukemic cells in the cerebrospinal fluid (CSF). In patients with meningeal leukemia, elevation of CSF protein concentration occurs inconsistently. The present study was undertaken to determine whether changes in the electrophoretic distribution of CSF proteins occur that could be useful in the early diagnosis of the disease and in following the response to therapy.

Methods

Of the 19 patients included in this study, 17 had acute leukemia, 1 had Hodgkin's disease, ana 1 had congenital mental deficiency. Of the 17 patients with acute leukemia, 8 developed meningeal leukemia. The CSF was examined in 3 patients during periods of active meningeal leukemia and when no evidence of meningeal leukemia was present. The diagnosis of acute leukemia was confirmed by the presence of abnormal cells in both the peripheral blood and the bone marrow. Meningeal leukemia was confirmed by the presence of abnormal cells in the CSF.11

The 13 patients with acute leukemia who did not have meningeal leukemia and the 2

From the Medicine Branch, National Cancer Institute, of the