Familial Mediterranean Fever (FMF) is a recessive inherited disorder affecting Sephardic Jews, Arabs, Armenians and Turks. The gene responsible for FMF was recently cloned and several disease-associated mutations have been described. We have evaluated seven MEFV mutations in 460 chromosomes of 230 u
MEFV mutations in Egyptian patients suffering from familial Mediterranean fever: analysis of 12 gene mutations
โ Scribed by Ayman El-Garf; Samia Salah; Iman Iskander; Hala Salah; Sherif Naseh Amin
- Publisher
- Springer
- Year
- 2009
- Tongue
- English
- Weight
- 240 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0172-8172
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๐ SIMILAR VOLUMES
The MEFV gene involved in familial Mediterranean fever was recently cloned and four distinct sequence alterations (M680I, M694V, M694I and V726A) were identified at the 3'-most exon. We genotyped 170 unrelated FMF patients from various ethnic groups in Israel and found that mutation M694V predominat
## Abstract ## Objective Familial Mediterranean fever (FMF) is an autosomalโrecessive disorder that is common in Armenian, Turkish, Arab, and Sephardic Jewish populations. Its clinical diagnosis is one of exclusion, with the patients displaying nonspecific symptoms related to serosal inflammation.
Familial Mediterranean fever (FMF) is an autosomal recessively inherited disease affecting patients of the Mediterranean basin. FMF is characterized by recurrent episodes of fever accompanied with topical signs of inflammation. Some patients can develop a renal amyloidosis associated (AA) amyloidosi