Medullary Thyroid Carcinoma

✍ Scribed by F. Raue, A. Zink, H. Scherübl (auth.), Prof. Dr. Friedhelm Raue (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1992
• Tongue: English
• Leaves: 216
• Series: Recent Results in Cancer Research 125
• Edition: 1
• Category: Library

✦ Synopsis

Medullary Thyroid Carcinoma is a rare thyroid tumor originating from neural crest cells, the C-cell that implies several special features, secretion of different neuroendocrine markers, association with other endocrine tumors and familial appearance. The familial variant of medullary thyroid carcinoma allows an early detection by biochemical and genetic testing. At that stage acceptable surgical treatment will cure the patient. The sporadic form of medullary thyroid carcinoma will be diagnosed in a progressive stage, but adequate surgical procedure can cure these patients too. Long term survival depends on stage, age, sex, and variant of the disease and seems to be as good as in other differentiated thyroid cancers.

✦ Table of Contents

Front Matter....Pages I-IX
Regulation of Calcitonin Secretion and Calcitonin Gene Expression....Pages 1-18
Pathology of Sporadic and Hereditary Medullary Thyroid Carcinoma....Pages 19-45
Epidemiology of Medullary Thyroid Carcinoma....Pages 47-54
Tumor Markers for the Medullary Thyroid Carcinoma....Pages 55-89
Sporadic Medullary Thyroid Carcinoma: Clinical Features and Diagnosis....Pages 91-104
Screening for MEN 2 with Biochemical and Genetic Markers....Pages 105-123
Imaging Methods for Medullary Thyroid Cancer....Pages 125-145
Surgical Strategies and Methods for the Treatment of Metastasizing Medullary Thyroid Carcinoma....Pages 147-165
Surgical Management of MEN 2....Pages 167-195
Postsurgical Follow-Up and Management....Pages 197-211
Back Matter....Pages 213-216

✦ Subjects

Oncology; Neurosciences; Internal Medicine