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Medium- and Long-Distance 1H–13C Heteronuclear Correlation NMR in Solids

✍ Scribed by X.L. Yao; K. Schmidt-Rohr; M. Hong

Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
75 KB
Volume
149
Category
Article
ISSN
1090-7807

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✦ Synopsis

A simple method for obtaining 1 H-13 C HETCOR solid-state NMR spectra reflecting only medium-and long-range 1 H-13 C correlation peaks is presented. By dephasing the magnetization of protons directly bonded to a 13 C nucleus, the short-range correlation peaks, which contain limited structural information, can be cleanly suppressed without reducing the long-range cross peaks significantly. The resulting reduction of resonance overlap simplifies spectral assignment. The dephasing of the intensity of a given peak in the HETCOR spectrum traces out a 1 H-13 C distance-dependent REDOR curve. This medium-and long-distance (MELODI) HETCOR experiment is demonstrated on a mixture of amino acids with 13 C in natural abundance. It is useful for resonance assignment of proteins and other organic solids with partial or no 13 C labeling.

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