Medicinal Chemistry Driven Approaches Toward Novel and Selective Serotonin 5-HT6 Receptor Ligands
✍ Scribed by Holenz, Jörg; Mercè, Ramon; Díaz, José Luis; Guitart, Xavier; Codony, Xavier; Dordal, Alberto; Romero, Gonzalo; Torrens, Antoni; Mas, Josep; Andaluz, Blas
- Book ID
- 111653987
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 349 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-2623
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📜 SIMILAR VOLUMES
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a] indoles are synthesized using a sixstep protocol. Notably, the synthesis route make use of a new and improved ring-closing methodology for the assembly of the hexahydro-pyrazino[1,2-a]indole scaffold, which is based on intramolecular C
## Abstract A variety of novel 7‐sulfanylpyrazinoindole derivatives (V) (11 examples) is synthesized using a new and improved ring‐closing methodology for the assembly of the hexahydropyrazinol[1,2‐α]indole scaffold.