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Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands

✍ Scribed by N. Krogsgaard-Larsen; A.A. Jensen; J. Kehler

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 268 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.07.105

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✦ Synopsis

Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]

indoles are synthesized using a sixstep protocol. Notably, the synthesis route make use of a new and improved ring-closing methodology for the assembly of the hexahydro-pyrazino[1,2-a]indole scaffold, which is based on intramolecular C-H insertion of a carbene. The compounds act as dual serotonin 5-HT 2C -and 5-HT 6 -ligands.

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