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Medical genetics: Retinoblastoma and recessive alleles in tumorigenesis

✍ Scribed by Gilbert, Fred

Book ID
109732446
Publisher
Nature Publishing Group
Year
1983
Tongue
English
Weight
260 KB
Volume
305
Category
Article
ISSN
0028-0836

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The retinoblastoma susceptibility (RB1) gene contains an unmethylated CpG-rich island at its 5' end. Using methylation-sensitive restriction enzymes, we have investigated the methylation status of this island in 21 sporadic unilateral retinoblastomas and 30 hereditary retinoblastomas. Three sporadic