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Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

✍ Scribed by Cavenee, W. K.; Dryja, T. P.; Phillips, R. A.; Benedict, W. F.; Godbout, R.; Gallie, B. L.; Murphree, A. L.; Strong, L. C.; White, R. L.

Book ID
118674740
Publisher
Nature Publishing Group
Year
1983
Tongue
English
Weight
823 KB
Volume
305
Category
Article
ISSN
0028-0836

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## Abstract The genetic hallmark of retinoblastoma is mutation or deletion of the __RB1__ gene, whereas other genetic alterations that are also required are largely unknown. To screen for genomic imbalances on a genomewide level, we studied a series of 17 primary retinoblastomas by matrix‐based com