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Mediators of endoplasmic reticulum stress-induced apoptosis

✍ Scribed by Szegezdi, Eva; Logue, Susan E; Gorman, Adrienne M; Samali, Afshin

Book ID: 110033123
Publisher: Nature Publishing Group
Year: 2006
Tongue: English
Weight: 191 KB
Volume: 7
Category: Article
ISSN: 1469-221X
DOI: 10.1038/sj.embor.7400779

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## Abstract The unfolded protein response (UPR) is an evolutionary conserved adaptive mechanism that permits cells to react and adjust to conditions of endoplasmic reticulum (ER) stress. In addition to UPR, phosphatidylinositol 3‐kinase (PI3K)/Akt and extracellular signal regulated kinase (ERK) sig