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Mediator: the missing link in amyloid precursor protein nuclear signalling

✍ Scribed by Turner, Anthony J; Belyaev, Nikolai D; Nalivaeva, Natalia N

Book ID
109851696
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
70 KB
Volume
12
Category
Article
ISSN
1469-221X

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## Abstract The zinc metallopeptidase, neprilysin (NEP), is an endothelin‐1 degrading enzyme whose expression is extensively downregulated in prostate cancer. The expression of NEP in neuronal cells is regulated by intramembrane proteolysis of the amyloid precursor protein (APP) through its intrace