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P1-410: The intracellular domain of the amyloid-beta precursor protein is not involved in nuclear signaling

✍ Scribed by Sebastien S. Hebert; Lutgarde Serneels; Katleen Craessaerts; Carmen Derks; Bart De Strooper


Book ID
118462859
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
55 KB
Volume
2
Category
Article
ISSN
1552-5260

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## Abstract One of the pathologic hallmarks of Alzheimer's disease is the excessive deposition of β‐amyloid peptides (Aβ) in senile plaques. Aβ is generated when β‐amyloid precursor protein (APP) is cleaved sequentially by β‐secretase, identified as β‐site APP‐cleaving enzyme 1 (BACE1), and γ‐secre