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Mechercharmycins A and B, Cytotoxic Substances from Marine-derived Thermoactinomyces sp. YM3-251

✍ Scribed by Kanoh, Kaneo; Matsuo, Yoshihide; Adachi, Kyoko; Imagawa, Hiroshi; Nishizawa, Mugio; Shizuri, Yoshikazu


Book ID
109867643
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
181 KB
Volume
58
Category
Article
ISSN
0021-8820

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The ethanolic extract of the sponge Jaspis sp. collected in Vanuatu showed cytotoxicity against KB tumour cells (IC 95 =10 mg/ml). A bioassay-guided fractionation led to the isolation of two new cytotoxic sphingosine derivatives, jaspine A and jaspine B. Structures were elucidated by spectroscopic m