Mechanistic studies on the total synthesis of heterocyclic steroids: Attempts of synthesis of 4,6-diazasteroids

✍ Scribed by J.J. Artús; J-J. Bonet; A.E. Peña

• Publisher: Elsevier Science
• Year: 1973
• Tongue: French
• Weight: 200 KB
• Volume: 14
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)79807-8

✦ Synopsis

In the application of the so-called Torgov Synthesis *)(S h c eme 1) to the total synthesis of aromatic azosteroids, the following observations have been mode

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No. 34

Since for the condensation step on unsaturation in position 8 seems tobe required (y), the use of double bond isomerising catalysts has been essayed but without success. Also, the direct use of the unsaturated derivative 2 was attempted, but the effect of this modification could not be investigated since compound 2 gives 1,4-addi-tion products to the pyridine ring with lithium derivatives 10) .