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Mechanistic studies on the metabolic activation of acetaminophen in vivo

โœ Scribed by Hoffmann, Kurt Jurgen; Axworthy, Donald B.; Baillie, Thomas A.

Book ID
126424980
Publisher
American Chemical Society
Year
1990
Tongue
English
Weight
972 KB
Volume
3
Category
Article
ISSN
0893-228X

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The effects of acetaminophen on the metabolism of the isolated perfused rat liver were investigated. The following results were obtained: (1) Acetaminophen increased glucose release and glycolysis from endogenous glycogen (glycogenolysis). (2) Oxygen uptake, gluconeogenesis from either pyruvate or