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Mechanistic studies on carboxypeptidase A from goat pancreas: Role of arginine residue at the active site

โœ Scribed by Ramji D. Dua; Kamlesh Gupta


Book ID
115706713
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
677 KB
Volume
236
Category
Article
ISSN
0003-9861

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Molecular orbital study of the effects o
โœ Setsuko Nakagawa; Hideaki Umeyama ๐Ÿ“‚ Article ๐Ÿ“… 1981 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 370 KB

As part of a study of the catalytic mechanism of carboxypeptidase A, two proton transfers in the system Glu 270-H20-Zn-His 69-Asp 142 are treated with an ab initio MO method. Results show that the proton transfers are strongly affected by the environment. It is predicted that the proton between His