✦ LIBER ✦
Molecular orbital study of the effects of ionic amino acid residues on proton transfer energetics in the active site of carboxypeptidase a
✍ Scribed by Setsuko Nakagawa; Hideaki Umeyama
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 370 KB
- Volume
- 81
- Category
- Article
- ISSN
- 0009-2614
No coin nor oath required. For personal study only.
✦ Synopsis
As part of a study of the catalytic mechanism of carboxypeptidase A, two proton transfers in the system Glu 270-H20-Zn-His 69-Asp 142 are treated with an ab initio MO method. Results show that the proton transfers are strongly affected by the environment. It is predicted that the proton between His 69 and Asp 142 is covatently bonded to His 69.