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Mechanistic Diversity in a Metalloenzyme Superfamily †

✍ Scribed by Armstrong, Richard N.

Book ID
126909191
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
346 KB
Volume
39
Category
Article
ISSN
0006-2960

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The strategy that nature has used to evolve new catalytic activities from pre-existing enzymes (i.e. retention of substrate binding or of catalytic mechanism) has been controversial. Recent work supports a strategy in which a partial reaction, catalyzed by a progenitor, is retained, and the active-s