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A gold standard set of mechanistically diverse enzyme superfamilies

✍ Scribed by Shoshana D Brown, John A Gerlt, Jennifer L Seffernick, Patricia C Babbitt


Book ID
120702301
Publisher
BioMed Central
Year
2006
Tongue
English
Weight
440 KB
Volume
7
Category
Article
ISSN
1465-6906

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Mechanistically diverse enzyme superfami
✍ John A Gerlt; Patricia C Babbitt πŸ“‚ Article πŸ“… 1998 πŸ› Elsevier Science 🌐 English βš– 779 KB

The strategy that nature has used to evolve new catalytic activities from pre-existing enzymes (i.e. retention of substrate binding or of catalytic mechanism) has been controversial. Recent work supports a strategy in which a partial reaction, catalyzed by a progenitor, is retained, and the active-s