Mechanistic Concepts in Androgen-dependence of Prostate Cancer
โ Scribed by Noah Craft; Charles L. Sawyers
- Book ID
- 110232504
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 71 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0167-7659
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Endocrine therapy for advanced prostate cancer is based on androgen ablation or blockade of the androgen receptor (AR). AR action in prostate cancer has been investigated in a number of cell lines, their derivatives, and transgenic animals. AR expression is heterogenous in prostate canc
## Abstract The importance of androgens and androgen receptors (AR) in primary prostate cancer is well established. Metastatic disease is usually treated with some form of androgen ablation, which is effective for a limited amount of time. The role of AR in prostate cancers that recur despite andro
## Abstract Protein serine/threonine kinase casein kinase 2 (CK2) is a key player in cell growth and proliferation but is also a potent suppressor of apoptosis. CK2 has been found to be dysregulated in all the cancers that have been examined, including prostate cancer. Investigations of CK2 signali