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Mechanisms underlying epigenetically mediated gene silencing in cancer

โœ Scribed by Stephen B Baylin


Book ID
114340572
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
163 KB
Volume
12
Category
Article
ISSN
1044-579X

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Maspin is a tumor suppressor whose expression is lost in many advanced breast cancers. Maspin has been shown to inhibit cell motility, invasion and metastasis; however, its precise role in normal mammary epithelium remains to be elucidated. Although expression of maspin mRNA is low or absent in most