Over 30 years after the original description of Randle's cycle, the mechanisms by which elevated circulating non-esterified fatty acids might be causally related to glucose intolerance in Type 2 diabetes mellitus remain uncertain. This review examines the evidence that elevated plasma NEFA can inhib
✦ LIBER ✦
Mechanisms of β cell failure in the pathogenesis of Type 2 diabetes
✍ Scribed by Domenico Accili
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 76 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0272-4391
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We examined the relationships of glucose and HbA1c levels with the routinely screened serum enzyme activities in type 2 diabetes mellitus, and we designed an __in vitro__ study to evaluate the direct effect of glucose levels on enzyme activities. The study was performed on a consecutive series of ou