Mechanisms of toxicity of 2- and 5-hydro
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Mary D'Arcy Doherty; Adrian Rodgers; Gerald M. Cohen
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Article
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1987
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John Wiley and Sons
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English
β 569 KB
The mechanisms of toxicity to isolated rat hepatocytes of two structurally related naphthoquinones have been studied. Both 5-OH-1,4-naphthoquinone (5-OH-1,4-NQ; juglone) and 2-OH-1,4-naphthoquinone (2-OH-1,4-NQ; lawsone) caused a concentration-dependent cytotoxicity to hepatocytes which was preceded