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Mechanisms of toxicity of naphthoquinones to isolated hepatocytes

✍ Scribed by Marion G. Miller; Adrian Rodgers; Gerald M. Cohen


Book ID
115778823
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
874 KB
Volume
35
Category
Article
ISSN
0006-2952

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✍ Mary D'Arcy Doherty; Adrian Rodgers; Gerald M. Cohen πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 569 KB

The mechanisms of toxicity to isolated rat hepatocytes of two structurally related naphthoquinones have been studied. Both 5-OH-1,4-naphthoquinone (5-OH-1,4-NQ; juglone) and 2-OH-1,4-naphthoquinone (2-OH-1,4-NQ; lawsone) caused a concentration-dependent cytotoxicity to hepatocytes which was preceded

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