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Mechanisms of toxic injury to isolated hepatocytes by 1-naphthol

✍ Scribed by Mary D'arcy Doherty; Gerald M. Cohen; Martyn T. Smith

Book ID
115777565
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
839 KB
Volume
33
Category
Article
ISSN
0006-2952

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πŸ“œ SIMILAR VOLUMES

Mechanisms of toxicity of 2- and 5-hydro
Mechanisms of toxicity of 2- and 5-hydroxy-1,4-naphthoquinone; absence of a role for redox cycling in the toxicity of 2-hydroxy-1,4-naphthoquinone to isolated hepatocytes
✍ Mary D'Arcy Doherty; Adrian Rodgers; Gerald M. Cohen πŸ“‚ Article πŸ“… 1987 πŸ› John Wiley and Sons 🌐 English βš– 569 KB

The mechanisms of toxicity to isolated rat hepatocytes of two structurally related naphthoquinones have been studied. Both 5-OH-1,4-naphthoquinone (5-OH-1,4-NQ; juglone) and 2-OH-1,4-naphthoquinone (2-OH-1,4-NQ; lawsone) caused a concentration-dependent cytotoxicity to hepatocytes which was preceded