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Mechanisms of resistance to methotrexate in childhood leukemia

✍ Scribed by M. Weigand; E. Frei; M. Wiessler

Book ID: 112784728
Publisher: Springer-Verlag
Year: 1995
Tongue: English
Weight: 158 KB
Volume: 121
Category: Article
ISSN: 1432-1335
DOI: 10.1007/bf02572185

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## Abstract ## BACKGROUND Although the majority of children with acute lymphoblastic leukemia (ALL) are cured with combination chemotherapy containing methotrexate (MTX), drug resistance contributes to treatment failure for a substantial fraction of patients. The primary transporter for folates an