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778 - Cellular mechanisms of resistance to methotrexate in childhood leukemia

โœ Scribed by M. Weigand; E. Frei; N. Gral; C. Wolfrom; B. Buchholz; M. Wiessler

Book ID
117665023
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
255 KB
Volume
33
Category
Article
ISSN
0959-8049

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๐Ÿ“œ SIMILAR VOLUMES

Reduced folate carrier mutations are not
Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia
โœ Yotam Kaufman; Stavit Drori; Peter D. Cole; Barton A. Kamen; Jenny Sirota; Ilan ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 257 KB

## Abstract ## BACKGROUND Although the majority of children with acute lymphoblastic leukemia (ALL) are cured with combination chemotherapy containing methotrexate (MTX), drug resistance contributes to treatment failure for a substantial fraction of patients. The primary transporter for folates an