Mechanisms of osteopenia in the first year of treatment for acute lymphoblastic leukaemia (ALL)
β Scribed by R.M. Cox; B.A. Evans; J.H. Davies; M.E. Jenney; W.D. Fraser; J.W. Gregory
- Book ID
- 116320047
- Publisher
- Elsevier Science
- Year
- 2007
- Tongue
- English
- Weight
- 98 KB
- Volume
- 40
- Category
- Article
- ISSN
- 8756-3282
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Serial liver function tests and percutaneous liver biopsies were performed on 21 children receiving treatment for acute lymphoblastic leukaemia (ALL). The patients received continuing chemotherapy either with daily 6-mercaptopurine and weekly methotrexate or with five-day pulses of these drugs every
Between 1976 and 1986, 2,093 children with ALL were enrolled in three consecutive generations of trials conducted by the Associazione ltaliana Ematologia Oncologia Pediatrica (AIEOP). A 50% event-free survival at 5 years was achieved overall in this population, approximately accounting for more than