## Abstract Immunoglobulin class switch recombination (CSR) is initiated by activation‐induced cytidine deaminase (AID), an enzyme that deaminates cytidine residues in single‐stranded DNA. U:G mismatches created by AID are processed to produce lesions that recruit and activate DNA damage response p
✦ LIBER ✦
Mechanisms of isotype determination during immunoglobulin class switch recombination in human B-cells
✍ Scribed by Fear, D.J.; McCloskey, N.; Felsenfeld, G.; Gould, H.
- Book ID
- 119275824
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 30 KB
- Volume
- 115
- Category
- Article
- ISSN
- 1097-6825
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## Abstract Ig class switch recombination (CSR) is dependent upon the expression of activation‐induced deaminase and targeted to specific isotypes by germ‐line transcript expression and isotype‐specific factors. NF‐κB plays critical roles in multiple aspects of B cell biology and has been implicate