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HIV-1 nef suppression of B-cell immunoglobulin heavy chain class-switch recombination

✍ Scribed by Jamila C. Martin; Sapandeep K. Singh; David P. Huston

Book ID
107533449
Publisher
Current Science Inc.
Year
2006
Tongue
English
Weight
63 KB
Volume
6
Category
Article
ISSN
1529-7322

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## Abstract Immunoglobulin class switch recombination (CSR) is initiated by activation‐induced cytidine deaminase (AID), an enzyme that deaminates cytidine residues in single‐stranded DNA. U:G mismatches created by AID are processed to produce lesions that recruit and activate DNA damage response p