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Mechanisms of immune evasion by renal cell carcinoma: tumor-induced T-lymphocyte apoptosis and NFκB suppression

✍ Scribed by Christopher S Ng; Andrew C Novick; Charles S Tannenbaum; Ronald M Bukowski; James H Finke


Book ID
117264112
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
93 KB
Volume
59
Category
Article
ISSN
0090-4295

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## Abstract The transcription factor nuclear factor‐κB (NF‐κB) has been shown to be constitutively activated in various human malignancies, including leukemia, lymphoma and a number of solid tumors. NF‐κB regulates the transcriptional of genes important for tumor invasion, metastasis and chemoresis