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Mechanisms of Granulin Deficiency: Lessons from Cellular and Animal Models

✍ Scribed by Kleinberger, Gernot; Capell, Anja; Haass, Christian; Van Broeckhoven, Christine


Book ID
118822033
Publisher
Springer
Year
2012
Tongue
English
Weight
788 KB
Volume
47
Category
Article
ISSN
0893-7648

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## Abstract Myelodysplastic syndrome (MDS) is a clonal disorder of hematopietic stem cells characterized by ineffective hematopoiesis, peripheral blood cytopenia, morphologic dysplasia, and susceptibility to acute myeloid leukemia. Several mechanisms have been suggested as causes of MDS: unbalanced