✦ LIBER ✦

Molecular bases of myelodysplastic syndromes: Lessons from animal models

✍ Scribed by Yukiko Komeno; Jiro Kitaura; Toshio Kitamura

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 157 KB
Volume: 219
Category: Article
ISSN: 0021-9541
DOI: 10.1002/jcp.21739

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Myelodysplastic syndrome (MDS) is a clonal disorder of hematopietic stem cells characterized by ineffective hematopoiesis, peripheral blood cytopenia, morphologic dysplasia, and susceptibility to acute myeloid leukemia. Several mechanisms have been suggested as causes of MDS: unbalanced chromosomal abnormalities reflecting a gain or loss of chromosomal material, point mutations of transcription factors, and inactivation of p53. However, appropriate animal models that mimic MDS have long been lacking. We recently reported a novel murine model of MDS that recapitulates trilineage dysplasia and transformation to AML. In this review, we summarize the animal models of MDS and discuss the molecular bases of MDS as well as those of leukemia and myeloproliferative disorders (MPD). J. Cell. Physiol. 219: 529–534, 2009. © 2009 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Are there non-catalytic functions of ace

Are there non-catalytic functions of acetylcholinesterases? Lessons from mutant animal models

✍ Xavier Cousin; Uwe Strähle; Arnaud Chatonnet 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 236 KB

Acetylcholinesterase (AChE) hydrolyses acetylcholine (ACh) ensuring the fast clearance of released neurotransmitter at cholinergic synapses. Many studies led to the hypothesis that AChE and the closely related enzyme butyrylcholinesterase (BChE) may play other, non-hydrolytic roles during developmen

Antibiotic prophylaxis and treatment of

Antibiotic prophylaxis and treatment of reactive arthritis. Lessons from an animal model

✍ Yong Zhang; Christel Gripenberg-Lerche; Karl-ove Söderström; Auli Toivanen; Paav 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 535 KB

What we know about facilitative glucose

What we know about facilitative glucose transporters: Lessons from cultured cells, animal models, and human studies

✍ Naira Gorovits; Maureen J. Charron 📂 Article 📅 2003 🏛 The American Society for Biochemistry and Molecula 🌐 English ⚖ 216 KB

Clinical, molecular, and animal model st

Clinical, molecular, and animal model studies in Cornelia de Lange syndrome and the cohesinopathies: Abstracts from the 3rd Scientific Cornelia de Lange Syndrome Symposium, 2008

✍ Antonie D. Kline 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB 👁 3 views

Establishment and characterization of im

Establishment and characterization of immortalized neuronal cell lines derived from the spinal cord of normal and trisomy 16 fetal mice, an animal model of Down syndrome

✍ Ana María Cárdenas; David D. Allen; Christian Arriagada; Alexis Olivares; Lori B 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 486 KB

## Abstract We report the establishment of continuously growing cell lines from spinal cords of normal and trisomy 16 fetal mice. We show that both cell lines, named M4b (derived from a normal animal) and MTh (trisomic) possess neurological markers by immunohistochemistry (neuron specific enolase,

Knockdown of amyloid precursor protein n

Knockdown of amyloid precursor protein normalizes cholinergic function in a cell line derived from the cerebral cortex of a trisomy 16 mouse: An animal model of down syndrome

✍ Patricia Opazo; Katherine Saud; Michelle de Saint Pierre; Ana María Cárdenas; Da 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 307 KB

## Abstract We have generated immortal neuronal cell lines from normal and trisomy 16 (Ts16) mice, a model for Down syndrome (DS). Ts16 lines overexpress DS‐related genes (__App__, amyloid precursor protein; __Sod1__, Cu/Zn superoxide dismutase) and show altered cholinergic function (reduced cholin