Mechanisms of dissolution of human cholesterol gallstones

✍ Scribed by William I. Higuchi; Sompol Prakongpan; Fudah Young

• Publisher: John Wiley and Sons
• Year: 1973
• Tongue: English
• Weight: 411 KB
• Volume: 62
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600620618

✦ Synopsis

to Model I in ethanol-water and acetone-water solvent mixtures. In 5 x cholate, the rates appear to be somewhat slower than the predictions of Model I; in bile salt-lecithin solutions, the rates appear to be more than a factor of 10 slower. In Fig. , the data of Small (2) are compared to some theoretical calculations, As can be seen, rates based upon Model I appear to be significantly greater than Small's in v i m results. These preliminary comparisons of experimental results with the theoretical relationships show that under physiologically important conditions, the simple diffusion-controlled model may or m a y not be applicable and that careful scrutiny of the various factors is necessary.

From the clinical standpoint, the idea that a 2.5-mm. gallstone might be dissolved in a few days is very appealing. Therefore, the question of why the observed rates might be significantly slower than diffusion controlled is important clinically.