Mechanisms of Disease: cancer targeting and the impact of oncogenic RET for medullary thyroid carcinoma therapy
✍ Scribed by Drosten, Matthias; Pützer, Brigitte M
- Book ID
- 118149138
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 347 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1743-4254
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Germline and somatic mutations of the RET proto-oncogene are important pathogenetic factors in hereditary and sporadic forms of medullary thyroid carcinoma (MTC). We have therefore analysed exons 10, I I. 13, 14 and 16 of this gene in 85 individuals from 16 Austrian families who, according to clinic