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Analysis of alternative mechanisms for RET gene activation in hereditary and sporadic Medullary Thyroid Carcinoma

✍ Scribed by Ciampi Raffaele; Romei Cristina; Vivaldi Agnese; Cosci Barbara; Tacito Alessia; Renzini Giulia; Bottici Valeria; Basolo Fulvio; Pinchera Aldo; Elisei Rossella


Book ID
113513815
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
41 KB
Volume
203
Category
Article
ISSN
0165-4608

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Germline and somatic mutations of the RET proto-oncogene are important pathogenetic factors in hereditary and sporadic forms of medullary thyroid carcinoma (MTC). We have therefore analysed exons 10, I I. 13, 14 and 16 of this gene in 85 individuals from 16 Austrian families who, according to clinic