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Mechanisms of chiral recognition in xenobiotic metabolism and drug-receptor interactions

✍ Scribed by Bernard Testa

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 379 KB
Volume: 1
Category: Article
ISSN: 0899-0042
DOI: 10.1002/chir.530010104

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## Abstract The metabolism of the nonsteroidal antiinflammatory drug flobufen, 4‐(2′,4′‐difluorobiphenyl‐4‐yl)‐2‐methyl‐4‐oxobutanoic acid, was studied in primary cultures of human hepatocytes prepared by two‐step collagenase perfusion of livers from four donors. Racemic flobufen or its individual