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Mechanisms of cartilage degradation: Relation to choice of therapeutic agent

✍ Scribed by Theodore Derek Vernon Cooke

Book ID
114098496
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
951 KB
Volume
15
Category
Article
ISSN
0049-0172

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## Abstract To aid in designing new therapeutic iron chelating agents, the mechanism of iron binding to prototypic heterocyclic carboxaldehyde thiosemicarbazones has been studied. Based on molecular orbital and spectroscopic studies, iron (II) is found to bind in a covalent manner, while iron(III)